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HLA :

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Human leucocyte antigens. These are cell surface proteins, detected by blood testing, that vary from person to person. They are also called tissue antigens or histocompatibility antigens because ideally organ donors and recipients must have compatible HLA; otherwise the transplanted organ is recognized as nonself ('foreign') and is rejected. HLA are related to the workings of the immune system; they present selfand foreign-derived (e.g. viral) peptides (a few amino acids linked together) to T lymphocytes and other cells of the immune system that help the body fight illness. They are of two broad types, called class I and class II HLA. Their genes are located on chromosome 6; the loci are given the letters A, B, C, D, and so on.


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