any large scale calamity (especially when thought to be sent by God)
any epidemic disease with a high death rate
a serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of an infected rat flea (especially bubonic plague)
a swarm of insects that attack plants; "a plague of grasshoppers"
cause to suffer a blight; "Too much rain may blight the garden with mold"
annoy continually or chronically; "He is known to harry his staff when he is overworked"; "This man harasses his female co-workers"
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