Medical Dictionary
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An alphabetical listing of General terms and items. |
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A measure of probability that is reported with clinical trial results. The p-value indicates the likelihood the result obtained are due to chance alone. Traditionally, a p-value of less than .05 is considered statistically significant, or not likely due to chance alone. See also confidence interval.
Greek pachys = thick, and meninx = membrane; hence, the thick membrane covering the central nervous system, i.e., dura mater.
A disease characterized by accelerated bone turnover, resulting in the involved bone becoming enlarged but weak and fragile. The bone also feels warmer to touch due to increased blood supply. Also called osteitis deformans.
Greek palaios = old; hence, palaeocerebellum, the earliest stage in the evolution of the cerebellum.
Latin palatum = palate, adjective - palatal or palatine.
Greek palaios = old; hence, paleocerebellum, the earliest stage in the evolution of the cerebellum.
Offering symptomatic relief and comfort care (e.g., alleviation of pain) rather than a cure.
Adjective, Latin = pale.
Latin = cloak; hence, the cerebral cortex forming the outer covering of the cerebral hemisphere.
Paleness.
Latin palma = palm; adjective, palmar - Latin palmaris.
Able to be felt (see Breast Cancer).
Latin palpare = to touch, and palpatus = touched; hence, to examine by feeling, and palpation, such an examination.
Latin = eyelid, probably from palpitare = to flutter.
Adjective, Latin pampinus = tendril, and forma = shape.
A digestive gland in the abdominal cavity that secretes digestive enzymes.
Inflammation of the pancreas.
An abnormally low level of all types of blood cells, typically due to bone marrow damage.
Diminutive of Latin pannus = cloth.
Latin = nipple or teat; adjective - papillary.
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A procedure to remove fluid that has accumulated in the abdominal cavity—a condition called ascites.
See acetaminophen
Greek para = beside of near, and didymis = twinned or paired, refers to testes; hence the collection of convoluted tubules in the spermatic cord, above the head of the epididymis.
Greek para = beside, and aisthesia = sensation; hence, abnormal sensation, usually burning or pricking.
Greek para = beside, near, lyein = to loosen; hence loss or impairment of muscle function.
Greek para = beside, and metra = womb; hence, connective tissue alongside the body of the uterus, within the broad ligament.
Greek para = beside, and plege = a stroke; hence, paralysis of the lower limbs.
Adjective, Greek para = beside, Latin ren = kidney; hence, beside the kidney, e.g., pararenal fat, the fatty capsule of the kidney.
Adjective, Greek para = beside, and sternon = chest; hence, the parasternal line is a vertical line about midway between the sternal edge and the midclavicular line.
Adjective, Greek para = beside, syn = with, and pathos = feeling; hence, the division of the autonomic nervous system complementary to the sympathetic system.
Adjective, Greek para = beside, and thyroid; hence, beside the thyroid gland.
A hormone that regulates calcium levels. It prevents the level of blood calcium from going too low by stimulating the breakdown of bone. In addition to triggering bone loss, it can stimulate bone formation. Given appropriately, it can increase bone mass, and is used as a treatment for osteoporosis (see Osteoporosis).
Greek para = beside or near, en = in, and chein = to pour; hence a general term to designate the functional elements of an organ, as opposed to the framework or stroma.
Nutrients given by injection into a vein, bypassing the gastrointestinal tract.
Greek = relaxation, but has come to mean partial paralysis.
Adjective, Latin parietalis, pertaining to paries = wall.
Adjective, Greek para = beside, and otos = of the ear; hence, beside the ear.
Adjective, Latin pario = I bear (children); hence, adjective, applied to woman who has borne one or more children (cf. nulliparous, multiparous).
Latin = part.
A skin test used to diagnose contact dermatitis (see Allergies).
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Latin a small pan; adjective - patellar.
Any disease-causing agent, especially a microorganism (bacteria, virus, fungus, parasite).
The development and progression of a disease.
The study of disease, including the causes, development, and progression of disease, and how the body is affected.
Same as oligoarthritis.
See polymerase chain reaction.
Peritoneal dialysis
The greatest amount of bone tissue that a person has during his or her life; typically reached by age 30 (see Osteoporosis).
A measure of how fast you can blow air out of your lungs. In asthma, your peak flow reflects the extent to which your bronchial tubes are normally open or abnormally narrowed (see Asthma).
A simple handheld device used to assess lung function, commonly used to diagnose and monitor asthma (see Allergies, Asthma).
The highest level of drug reached in the body after a dose is taken. Contrast with trough level.
Latin = comb.
Adjective, from Latin pecten = a comb; applied to structures having the appearance of parallel teeth arising from a straight back (musculi pectinati), or the sellar appearance of the superior pubic ramus, which may have resembled the body of antique combs.
Adjective, from Latin pecten = a comb; applied to structures having the appearance of parallel teeth arising from a straight back (musculi pectinati), or the sellar appearance of the superior pubic ramus, which may have resembled the body of antique combs.
Latin, pecten = a comb; hence the muscle attaching to the pecten (pectineal line) of the pubic bone.
Adjective, Latin pectoris = of the front of the chest.
Adjective, Latin pectoris = of the front of the chest.
Diminutive of Latin pedis = of the foot.
Latin = of the foot.
Variation of pedicle.
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Brand name of pegylated interferon-alpha-2b, produced by Schering-Plough.
Brand name of pegylated interferon-alpha-2a, produced by Genentech Inc.
See pegylated interferon.
A recently developed form of interferon that has a long half-life in the body and can be injected less often (typically once per week). Pegylated interferon (brand names Peg-Intron, Pegasys) appears superior to standard interferon as a treatment for HCV.
A process in which polyethylene glycol (PEG) molecules are attached to proteins in order to extend their activity in the body.
See percutaneous ethanol injection.
Adjective, Latin per = through, and lucere - to shine; hence, translucent.
The supportive network of muscles that extends from the pubic bone to the tailbone with openings for the urethra, the anus, and in women, the vagina (see Urinary Incontinence).
The bony structures in the lowest part of the trunk. The term pelvic is used for anything that belongs or refers to the pelvis.
Latin = tail, the male organ of copulation (cf. appendix, appendage).
Latin penna = feather; hence, a muscle whose fibres approach the tendon from one direction is unipennate; from two, bipennate, and from more than two, multipennate.
(pinnate) - adjective, Latin penna = feather; hence, a muscle whose fibres approach the tendon from one direction is unipennate; from two, bipennate, and from more than two, multipennate.
A name for several enzymes secreted by the stomach to break down protein (see Digestive Health).
A sore in the lining of the stomach (gastric ulcer) or duodenum (duodenal ulcer). The word peptic refers to the stomach and the duodenum, where pepsin is present, an enzyme that breaks down proteins. An ulcer can sometimes occur in the lower part of the esophagus in association with heartburn.
A few amino acids linked together. Proteins are made of multiple pep tides linked together.
Through the skin.
A treatment for hepatocellular carcinoma in which ethanol (alcohol) is injected into the tumor.
Adjective, Greek peri = around, and Latin anus = lower opening of alimentary canal.
Greek peri = around, and kardia = heart; hence, the membranes enclosing the heart.
Greek peri = around, and chondros = cartilage; hence, the membrane covering cartilage.
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Greek peri = around, and kranion = skull; hence, the external periosteum of the skull.
Inflammation of the lining of the liver.
Greek peri = around, and lympha - Latin = clear water; hence, the fluid in the bony labyrinth surrounding the membranous labyrinth (and continuous with the cerebrospinal fluid).
The phase starting when periods become irregular and lasting until a year after the last period (see Menopause).
The period around the time of birth.
See vertical transmission.
Greek the caudal aspect of the trunk between the thighs, or, the region of the trunk below the pelvic diaphragm; adjective - perineal.
Adjective, Greek peri = around, and odont = tooth.
Greek peri = around, and osteon = bone; hence, the membrane around a bone.
Adjective, Greek peri = around and phero = carry; hence, away from the centre (cf. periphery).
Damage to the peripheral nerves, usually involving the feet and hands.
A disorder caused by the blockage of blood vessels to the brain and extremities (see Diabetes).
Greek peri = around, and stellein - to constrict; hence, a circular constriction passing as a wave along a tube; adjective - peristaltic.
The thick membrane that lines the abdominal cavity and covers the visceral organs.
Inflammation of the peritoneum.
A type of anemia caused by the inability of the intestine to absorb vitamin B12, which is needed to produce red blood cells.
An electromechanical device that electronically gathers data that is then used to calculate limb volume.
Adjective, Greek perone = clasp, brooch - see fibula.
Latin = foot.
A device worn in the vagina to support or correct the position of the uterus, rectum, or bladder (see Urinary Incontinence).
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Adjective, Latin petrosus = rocky.
Adjective, Latin petrosus = rocky.
Darkly pigmented.
A scavenger cell that engulfs and destroys invading pathogens (phagocytosis).
Latin = row of soldiers; hence, one of the small bones of a digit, plural - phalanges, adjective - phalangeal.
Greek phallos = penis.
Having to do with the development and manufacture of drugs, or to a manufactured drug.
The action of drugs in the body, including the processes of absorption, metabolism, distribution to tissues, and elimination.
The science of drugs, their sources, and how they work.
Greek = throat; adjective - pharyngeal.
The first stage of human testing of a new treatment. Phase I trials evaluate drug pharmacokinetics, safety, and toxicity at different dose levels, typically in a small number of healthy volunteers.
The second stage of the evaluation of a new treatment in humans. Phase II trials evaluate safety and preliminary efficacy in a larger number of participants than Phase I studies.
The third stage of human testing of an experimental treatment. Phase III trials are designed to determine the efficacy of a treatment, often by comparing it to an existing standard therapy or a placebo.
Post-marketing studies done after a new treatment is approved and offered for sale. These trials provide additional information about safety and efficacy in large numbers of patients under "real world" conditions.
Greek philtron - the median sulcus of the upper lip. Derivation doubtful.
Another term meaning chronic venous insufficiency. Also spelled phelbo-lymphedema.
Withdrawal of blood from a vein.
Greek phone = sound or voice; hence, the production of either.
An increased sensitivity to light, which may lead to easy sunburning and other adverse effects.
Greek phren = diaphragm or mind; hence, diaphragmatic (cf. schizophrenic).
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Tropical plant species that traditionally have been used to treat liver conditions.
Latin = faithful, hence, the membrane which faithfully follows the contour of the brain and spinal cord.
A substance responsible for the color of bodily tissues.
Latin pilus = a hair, and movere = to move; hence the action of the arrectores pilorum muscles.
Latin = a hair.
Adjective, Latin pinea = a pine cone; hence, the pineal gland which is cone-shaped.
Adjective, Latin pirum = a pear; hence, pear-shaped.
Adjective, Latin pisum = a pea; hence, pea-shaped.
When a swollen area is pressed, the pressure leaves an indentation (pit) that slowly fills in again.
Latin pituita = mucous or phlegm, the gland was thought to produce mucous that discharged through the nose.
An endocrine gland tucked into a bony space beneath the brain. It receives input and influence from the hypothalamus. It produces adrenocorticotropic hormone (ACTH), which controls the secretion of cortisol by the adrenal glands. This helps trigger the "fight-or-flight" response (see Anxiety, Depression).
An inert, inactive agent (e.g., pill, injection) that has no treatment value.
The group of participants in a clinical trial that receives an inactive substance (placebo).
A change in symptoms or disease progression associated with the treatment process itself, rather than the actual therapeutic value of a treatment.
A clinical trial in which a group receiving an inactive substance or mock therapy (placebo) is compared to a group receiving the experimental treatment.
The organ that connects the fetus and the mother's uterus and enables the exchange of oxygen, nutrients, and waste products.
Greek plax = plate or flat, and eidos = shape or form.
Latin planus = flat; hence, a real or imaginary flat surface.
Latin the sole of the foot; adjective - plantar or plantaris.
Adjective, Latin planta = the sole of the foot.
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Deposits of cholesterol and fatty and fibrous substances in the walls of the arteries (see Cardiovascular Health).
The fluid, non-cellular portion of circulating blood. See also serum.
Descendants of B cells responsible for producing antibodies (see Allergies).
A procedure in which certain components are removed from the blood plasma.
See thrombocyte.
The number of platelets in the blood. People with advanced liver disease may have reduced platelet counts, resulting in easy bleeding. A normal platelet count is 130,000-400,000/mcl.
Minute, colorless disks in the blood that are instrumental in clotting (see Cardiovascular Health, High Cholesterol).
Greek = flat object; hence, the flat subcutaneous muscle extending from below the clavicle to the mouth.
Greek = a rib. Later used to name the serous membrane lining the chest walls and the lung on each side.
Latin = a network or plait.
Latin plicare = to fold; hence, a fold.
Greek pneuma = air.
Lung inflammation.
Taken by mouth.
Latin = thumb.
Genitive (possessive case) of Latin pollex = thumb; hence of the thumb.
Pains in many joints; conventionally refers to more than four joints, without signs of inflammation in the symptomatic joints.
Inflammation in many joints; conventionally in more than four joints.
A highly sensitive test that uses an amplification technique to detect small amounts of genetic material (DNA or RNA) in a blood or tissue sample.
An agent that inhibits viral replication by interfering with the polymerase enzyme.
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Fatty acids that are abundant in soybean, corn, cottonseed, safflower, and sunflower oils (see High Cholesterol).
Latin = bridge; adjective - pontine; part of the brain stem.
Latin poples = the ham or thigh, and sometimes, the knee; adjective, popliteal, referring to the fossa behind the knee or its contents.
A condition in which porphyrins build up in the body leading to symptoms including increased photosensitivity, skin damage, and discoloration.
A metabolic byproduct of hemoglobin production.
Latin = a gate, also Latin portare = to carry; hence, the portal system carries venous blood from the alimentary tract to the porta hepatis; adjective - portal.
High blood pressure in the portal vein that carries blood to the liver, caused by the development of fibrous scar tissue (cirrhosis) in the liver.
A series of veins from the small and large intestines, stomach, and spleen that join into the portal vein and are carried into the liver.
The blood vessel that carries oxygen-poor blood from the intestines to the liver for filtering.
Latin a pore or foramen; hence, the openings of the acoustic meatuses.
See Phase IV trial.
Adjective, Latin post = behind (in place or time).
Treatment given immediately following exposure to an infectious organism in an attempt to prevent the infection from taking hold in the body.
Treatment given immediately following exposure to an infectious organism in an attempt to prevent the infection from taking hold in the body.
The period following birth.
Latin positus = placed; hence, the position of the body as a whole at a given moment, e.g. erect, recumbent, prone, supine, sitting, kneeling.
An element and electrolyte responsible for the body’s growth and maintenance.
A statistical term used to describe the ability of a clinical trial to detect a particular result. Generally the power of a study increases as more participants are included or as the trial continues for a longer period of time.
In Ayurveda, the body's vital energy.
A condition in which a fasting plasma glucose test and/or an oral glucose tolerance test provide readings that are elevated, but not quite diabetic; raises the risk of diabetes (see Diabetes).
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Laboratory and animal studies on an experimental treatment prior to clinical trials in humans.
The potential development of Lymphedema before clinical indications, such as swelling, are observed.
Latin pre = before, and cuneus = wedge; hence, the parietal lobule anterior to the cuneus.
A condition that increases the risk of developing high blood pressure; defined as 120–139 mm Hg systolic pressure or 80–89 diastolic pressure (see Cardiovascular Health).
The period preceding birth, during which the fetus develops in the uterus.
Latin praeputium = foreskin (of penis or clitoris).
The observed number of people in a given population affected with a particular disease or condition at a given time, usually stated as the number of cases observed per 100 000 individuals, or listed as a percentage. In contrast with incidence, prevalence can be thought of as a snapshot of all existing cases at a specified time.
The number of individuals with a condition in a specific population. The prevalence rate is determined by dividing the number of people with the condition by the total population. Contrast with incidence.
A commonly used skin test to confirm hypersensitivity to a broad range of allergens that elicit an IgE-mediated response (see Allergies).
A physician who is responsible for the overall long term health maintenance of a patient.
An inherited form of lymphedema that affects both males and females and can develop at any time of life; PLE.
Bone loss that doesn't result from an identifiable pathological process (see Osteoporosis).
Latin primus = chief, and capere = to take; hence chief or principal.
The chief researcher conducting a clinical trial.
Latin = slender, elongated; hence, the vertical slip of muscle between the medial part of frontalis and the root of the nose.
Latin = going forwards, used to indicate growing out, i.e., an outgrowth, usually of bone, e.g., the zygomatic process of the temporal.
Latin going forwards, used to indicate growing out, i.e., an outgrowth, usually of bone, e.g., the zygomatic process of the temporal.
See erythropoietin.
A compound that is converted to an active drug within the body.
Latin pro = before, and fundus = bottom; hence profundus = deep.
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A female hormone with anti-estrogen effects. Progesterone prepares the uterus for the development of the fertilized ovum and maintains the uterus throughout pregnancy.
A synthetic compound that produces effects similar to those of progesterone (see Menopause).
Any hormone having the same effect as progesterone in the body; refers to both natural progesterone and synthetic progestin (see Menopause).
The probable end result or outcome of a disease.
A forecast of the probable course or outcome of a disease.
Development of a disease over time.
See granulocyte colony-stimulating factor.
When a part of the body drops from its normal position (see Urinary Incontinence).
Latin = projecting.
Latin promontorium = a headland, i.e., part of land jutting into the sea - used for a bony prominence.
Latin pronatus = bent forwards; hence to pronate = to turn the hand so that the palm faces posteriorly.
Latin pronatus = bent forwards; hence, recumbent face-down posture.
A measure taken to prevent a disease or condition.
Latin proprius = one's own, and captum = taken; hence, sensory impulses received by the joints and muscles within one's own body.
Latin pro = before, and sectum = cut. A dissection prepared for demonstration of anatomic structures.
Latin pro = before, and sectum = cut. One who prepares a dissection for demonstration.
Latin pro = in front, and Greek enkephalos = brain; hence, the part of the brain rostral to the midbrain.
A clinical trial in whichparticipants are selected and their progression is followed over time. Contrast with retrospective study.
Study clinical trial or study in which the method of data analysis is specified in a protocol before the study is begun (prospective). Patients are randomly assigned to receive either the study drug or an alternative treatment, and neither the patient nor the doctor conducting the study knows which treatment is being given to which patient (see also placebo).
Greek pro = before, and Latin = statum = stood; hence, something which stands before - the prostate stands before the urinary bladder.
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An agent that inhibits viral replication by interfering with the virus' protease enzyme.
A complex organic compound consisting of a sequence of amino acids folded in a specific configuration. Proteins are major components of living cells and are essential for bodily growth and repair.
A protein synthesized by the liver that is necessary for proper blood clotting.
A measure of blood clotting time. People with advanced liver disease may have a slower than normal PT. A normal PT is 10-12 seconds.
A written plan for a clinical trial, which typically includes details such as the hypothesis to be tested, who can participate, length of the trial, how the treatment under study will be administered, endpoints, and potential risks and benefits.
A group of drugs used to treat heartburn and peptic ulcer disease. These include omprezole (Prilosec), esomeprazole (Nexium) and pansoprazole (Prevacid).
Latin protractus = drawn out; hence, to put forwards (e.g., shoulder or mandible). Protraction - the act of protracting.
Latin protrudo = thrust forwards, e.g. the tongue; protrusion - the act of protruding.
Latin protubero = I bulge out; hence, a bulging bony feature (see tuber).
The part of a limb that is closest to the trunk. For example, the shoulder joint forms the proximal end of the upper extremity (opposite of distal).
Itchiness.
A fragile string of cells that result from the budding of blastoconidia that have remained attached to each other. The septa separating the cells are complete and there is no cytoplasmic connection, as is found in most true septate hypha.
Greek = loin.
A skin condition characterized by scaling and red patches, due to the overproduction of skin cells.
A form of rheumatoid arthritis associated with psoriasis.
A form of therapy that focuses on how life events, desires, and close relationships lead to conflict, symptoms such as anxiety or depression, and difficulty in managing life's tasks (see Depression).
A serious mental illness.
A term used to refer to factors that affect the psychological or social realm. Psychosocial factors (e.g., socioeconomic status, education, family situation) can have an important effect on disease risk and progression and are an essential aspect of a person's well-being.
Treatment of mental problems with non-medical therapies, in particular counseling.
A drug that affects psychological or mental functioning or behavior.
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Patient.
Greek pteron = wing; hence, the region where the tip of the greater wing of the sphenoid meets or is close to the parietal, separating the frontal from the squamous temporal; alternatively the region where these 4 bones meet.
Adjective, Greek pteryx = wing, and eidos = shape; hence, wing-shaped.
Greek = fall; hence, drooping of an eyelid, or descent of an internal organ.
Latin puber = adult; hence, the time when hair appears in the pubic region - i.e., near the pubis - as a secondary sexual characteristic.
Latin = adult or signs of manhood, hence the lower abdominal secondary sexual hair.
Adjective, Latin pudendus = shameful; hence, pertaining to the external genitalia.
The nerve that controls the muscles of the pelvic floor; plays an important role in urinary and fecal continence (see Urinary Incontinence).
Adjective, Latin pulmo = lung.
The development of fibrous tissue in the lungs.
Latin pulpa = a soft part of the body or tooth.
Latin pulpa = a soft part of the body or tooth, hence pulpy or soft.
The difference between your systolic and diastolic blood pressures. May help predict heart disease risk (see Hypertension).
Latin pulvinus = rounded cushion; the posterior end of the thalamus.
Latin = a sharp point; hence a very small point or orifice.
Latin pupilla = the central black orifice in the iris; adjective - pupillary.
See thrombocytopenic purpura.
Characterized by the accumulation of pus.
A thick, greenish-yellow fluid composed of dead white blood cells, killed microorganisms, and other cellular debris.
Latin = peel, husk or shell of fruit or seed (the external part of the lentiform nucleus).
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Greek pyelos = basin, and gramma = diagram; hence, radiograph of the renal pelvis (and usually of the ureter) after filling with contrast medium.
Greek = gate-keeper; hence, the part of the pyloric canal containing the sphincter, which guards the opening into the duodenum; adjective - pyloric.
Greek pyramis = a pyramid (solid with 3- or more-sided base, and flat sides meeting at the apex), adjective - pyramidal.
A hepatotoxic component found in plants of the Crotalaria, Senecio, and Heliotropium families.
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